B.T. Luke, Ph.D. (


Manager I: Simulation, Analysis & Mathematical Modeling Group (2009-Present)
Frederick National Laboratory for Cancer Research, operated by Leidos Biomedical Research, Inc., Frederick, Maryland
SAMM Group specializes in Computational Chemistry, Protein Modeling and Docking, Mathematical Analysis and Statistics, and Scientific Algorithm and Program Development.

Univeristy of Southern California, Los Angeles, CA (1975-1980)
Ph.D. Theoretical Chemistry
Advisor: Prof. Gerald A. Segal
Dissertation: Development of new multi-step numerical integration methods to solve for the eigenvalues of the vibrational Schrodinger equation.

California Institute of Technology, Pasadena, CA (1971-1975)
B.S. Biology
Advisor: Prof. Edward A. Lewis, 1995 Nobel Prize in Physiology or Medicine
Undergraduate Research: Study temperature effects on the development times and genetic mutations in drosophila.
B.S. Chemistry
Advisor: Prof. William A. Goddard

Post-Doctoral Fellowship (1981-1983)
Prof. John A. Pople, 1998 Nobel Prize in Chemistry
Carnegie-Mellon University, Pittsburgh, PA
Research: Develop methods for the theoretical determination of accurate heats of formation; structure and stability of small molecules; and a comparison of bonding in silicon and carbon compounds.

NSF Summer Research Fellowship (1974)
Prof. William A. Goddard
California Institute of Technology, Pasadena, CA, USA
Topic: Theoretically study nitrogen fixation by iron complexes.

Programmer Analyst IV (1995-2009)
SAIC-Frederick Inc., National Cancer Institute at Frederick, Frederick, MD
Software development in the areas of classification, biomarker identification, quantitative proteomics, survival analysis using Kaplan-Meier and Cox models, hypothesis testing using environmental and genomic data, and identifying polymorphism interactions for disease susceptibility.

Senior Marketing Support Specialist (1987-1995)
International Business Machines Corporation, Poughkeepsie, NY
Augment Computational Chemistry and Computational Biology software to effectively utilize vector and distributed processors.
Develop algorithms using Genetic Methods for conformational searches in flexible molecules and Feature Selection problems.

Staff Scientist (1983-1987)
SRI International, Menlo Park, CA
Research: Study the aerobic and anaerobic metabolism of cytochrome P450; QSAR study of peptide opiates.